Investigators at Harvard Medical School and McLean Hospital in Boston assessed the effects of cannabis inhalation on mood and neuropsychological performance in patients with BPD over a period of several weeks.
Researchers reported that bipolar patients experienced decreased levels of various clinical symptoms – including depression, mania, anger, and anxiety – after inhaling cannabis. Although marijuana-using subjects did perform more poorly on certain cognitive tests compared to healthy controls, these subjects performed no differently than did comparable BPD patients with no history of cannabis use.
Authors concluded: “[D]irect analyses of the marijuana-smoking BPD patients before and after marijuana use revealed notable symptom alleviation within four hours of smoking, [such as] …. significantly lower scores of anger, tension, [and] depression, as well as higher levels of vigor. … With regard to cognitive performance, marijuana smokers and BPD patients performed more poorly than healthy controls overall. However, within the BPD patients, impairment was observed regardless of marijuana use status. … Taken together, study findings suggest that marijuana use may result in at least short-term mood term stabilization for a subset of BPD patients, and further, that marijuana use does not have an additive, negative impact on cognitive performance in BPD patients.”
The study is the first clinical trial to examine the effects of cannabis on both mood and cognitive performance in BPD patients.
Bipolar disorder is estimated to affect some 5.7 million American adults.
Full text of the study, “A pilot investigation of the impact of bipolar disorder and marijuana use on cognitive function and mood,” appears online in PLoS ONE.
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